Signals in human breath related to Sarcoidosis. — Results of a feasibility study using MCC/IMS

Autor:	Alexander Bunkowski, P. Litterst, Jörg Ingo Baumbach, B Bödeker, Sabine Bader, Michael Westhoff
Rok vydání:	2009
Předmět:	Chromatography Breath gas analysis business.industry Chemistry Ion-mobility spectrometry Potential biomarkers medicine In patient Sarcoidosis medicine.disease Nuclear medicine business Spectroscopy
Zdroj:	International Journal for Ion Mobility Spectrometry. 12:73-79
ISSN:	1865-4584 1435-6163
DOI:	10.1007/s12127-009-0022-0
Popis:	Using a 63Ni—Ion Mobility Spectrometer (IMS) coupled with a Multi-Capillary Column (MCC) the signals obtained are considered to identify characteristic peaks of volatile compounds in exhaled human breath samples of 10 mL volume. The breath of 20 patients with sarcoidosis and suspicion of sarcoidosis because of mediastinal lymp node enlargement was investigated. It could be shown that a procedure related to a single peak in the IMS-chromatogram delivers a differentiation into the two groups of patients with confirmed sarcoidosis and such suffering no sarcoidosis. The potential biomarker is characterised by the following parameters inverse mobility (1/K0) 0.53 ± 0.01 Vs/cm2—retention time 22 ± 5 s. These results are a first step in breath analysis by MCC/IMS in patients with sarcoidosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::17ea9890168089911fbef4083ae75d1a https://doi.org/10.1007/s12127-009-0022-0 Zobrazit plný text záznamu Full text from SpringerLink