| Autor: |
Gorbunova, A.V., Dzhabrailova, B.A., Korpacheva, O.V. |
| Jazyk: |
ruština |
| Rok vydání: |
2016 |
| Předmět: |
|
| DOI: |
10.18454/irj.2016.44.051 |
| Popis: |
Hypoxia is one of the leading pathogenetic formation factors of myocardial dysfunction in the early posttraumatic period of the isolated heart experimental injury. Changes in the activity of the respective enzymes, or variations in the availability of certain energy substrates helps to regulate energy metabolism in hypoxia. Modern approach to improve function of the damaged myocardium is the use of metabolic cytoprotectors, trimetazidine and glutamine. Trimetazidine (25 mg/kg intraperitoneally 30 min before injury) and glutamine (enterally at a dose of 250 mg per 100 g of body weight daily for 10 days before the simulation of cardiac contusion) when applied separately, significantly reduce the frequency of arrhythmia during the early posttraumatic period of the isolated heart experimental injury, providing an indirect antiarrhythmic effect and positively affecting on the course of posttraumatic period. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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