Case Detection Testing for Primary Aldosteronism in Male Patients with Hypertension and Snoring
| Autor: | Guli Nuer, Delian Zhang, Suofeiya Abulikemu, Ju-hong Zhang, Menghui Wang, Jianqiong Kong, Zhitao Yan, Yinchun Wang, Hongjian Li, Ying Zhang, Nanfang Li, Xiangyang Zhang |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Aldosterone Receiver operating characteristic medicine.diagnostic_test business.industry Apnea Polysomnography medicine.disease Plasma renin activity respiratory tract diseases Obstructive sleep apnea chemistry.chemical_compound Primary aldosteronism Endocrinology chemistry Internal medicine medicine Cardiology medicine.symptom business Hypopnea |
| Zdroj: | Journal of Hypertension- Open Access. |
| ISSN: | 2167-1095 |
| DOI: | 10.4172/2167-1095.1000180 |
| Popis: | Objectives: Coexistence of primary aldosteronism and obstructive sleep apnea in hypertension is evidenced. However, aldosterone and renin activity is varying with apnea/hypopnea index changes in subjects with resistant hypertension. Thus, the aim is to investigate the optional cutoff value for aldosterone/renin activity to screen primary aldosteronism in patients with different status of apnea/hypopnea index. Methods: 271 hypertensive male snores were evaluated via polysomnography and divided into two groups, group with apnea/hypopnea index >15 events/h and with apnea/hypopnea index 15 ng/dL performed saline infusion test, after which aldosterone concentration>5 ng/dL was a sign of primary aldosteronism. Receiver operating characteristic curve was applied to explore appropriate cutoff value for aldosterone/renin activity. Results: 39 (14.4%) of the 271 were diagnosed with primary aldosteronism including 15 with apnea/hypopnea index 15 events/h. Area under receiver operating characteristic curve was 0.97 (95%CI 0.94-0.99) in the group with apnea/hypopnea index >15 events/h and 0.91 (95%CI 0.87-0.96) in the group with apnea/hypopnea index 15 events/h with sensitivity 100%, specificity 69.7%. Youden index is 0.9 for the group with apnea/hypopnea index 15 events/h. Conclusions: Optional cutoff values of aldosterone/renin activity to screening for primary aldosteronism should be considered in patients with different status of apnea/hypopnea index. |
| Databáze: | OpenAIRE |
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