S674 Incidence of Gastrointestinal Hemorrhage in Hospitalized COVID-19 Patients and Subsequent Clinical Outcomes
| Autor: | Samuel Tan, Nikolas St. Cyr, Justin Wagner, Aaron Douen, Ryan Panetti, John Trillo |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Mechanical ventilation
Gastrointestinal bleeding medicine.medical_specialty Hepatology business.industry medicine.medical_treatment Incidence (epidemiology) Gastroenterology Acute kidney injury Retrospective cohort study medicine.disease Coronary artery disease Diabetes mellitus Internal medicine medicine business Kidney disease |
| Zdroj: | American Journal of Gastroenterology. 116:S304-S305 |
| ISSN: | 1572-0241 0002-9270 |
| Popis: | Introduction: SARS-CoV-2 infection (COVID-19) is known for its pathologic effects on microvasculature and is proposed to afflict the gastrointestinal tract via the ACE2 receptors. We hypothesize that there is a higher incidence and an increased risk of mortality among Covid-19 patients with gastrointestinal bleeding (GIB). Methods: This retrospective study included 2,711 patients ages 18 years or older who tested positive for Covid-19 between March 2020 through March 2021 at a public hospital in New York City. GIB was documented based on clinical criteria and a decrease in hemoglobin level. Patients were divided into two groups, GIB and non-GIB. We examined baseline characteristics of sex and age, as well as comorbidities including diabetes mellitus type 2, chronic kidney disease (CKD), chronic obstructive pulmonary disease (COPD), coronary artery disease (CAD), hypertension (HTN), heart failure (HF), and proton pump inhibitor (PPI) use. We used T-test for statistical analysis of age and Pearson's chisquared test for the primary outcome of all-cause mortality and the secondary outcomes of acute kidney injury, vasopressor use, and mechanical ventilation. Results: Of 2,711 patients, 205 (incidence of 8.18%) developed GIB. Overall sample characteristics included mean age of 71.15 (SD=16.36) and 63.36 (SD=19.26) for GIB and non-GIB groups, respectively. Males comprised 54.6% of the GIB group and 54.1% of the non-GIB group. Baseline clinical characteristics except for sex significantly differed between groups (p |
| Databáze: | OpenAIRE |
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