Iron(III) Coordinated Polymeric Nanomaterial: A Next-Generation Theranostic Agent for High-Resolution T1-Weighted Magnetic Resonance Imaging and Anticancer Drug Delivery
| Autor: | Raja Shunmugam, Tapan K. Dash, Saikat Mukherjee, Ipsita Chakraborty, Diptendu Patra, Shantibhusan Senapati, Rangeet Bhattacharyya |
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| Rok vydání: | 2018 |
| Předmět: |
Chemistry
Biomedical Engineering Nanotechnology 02 engineering and technology ROMP Polyethylene glycol 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Biomaterials chemistry.chemical_compound Polymerization Drug delivery medicine Nanomedicine Doxorubicin Nanocarriers 0210 nano-technology Norbornene medicine.drug |
| Zdroj: | ACS Biomaterials Science & Engineering. 4:1738-1749 |
| ISSN: | 2373-9878 |
| DOI: | 10.1021/acsbiomaterials.8b00294 |
| Popis: | Theranostic-based nanomedicine plays a crucial role in the field of cancer therapy. This is due to having the capability to combine both therapy and diagnosis together in a single system. Herein a new class of metal–ligand-based nanocarrier in a norbornene backbone has been designed as a theranostic system. Fe3+-terpyridine complex (Fe-Tpy) has been used here as T1 contrast agent for high-resolution MR imaging, and hydrazone-linked doxorubicin is used for effective pH-responsive delivery. Polyethylene glycol functionalized with a folic acid (peg folate) motif is used to make the entire polymeric system dispersible in water for longer retention and site-specific therapy. All these specialty functional groups are anchored in a single system by using the ring-opening metathesis polymerization (ROMP) technique under the norbornene backbone. Relaxivity study and 1D image experiments have shown the utility of Fe-Tpy complex as an effective T1 contrast agent. In vitro studies are performed to confirm the promisi... |
| Databáze: | OpenAIRE |
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