ChemInform Abstract: New Syntheses of 1D- and 1L-1,2-Anhydro-myo-inositol and Assessment of Their Glycosidase Inhibitory Activities

Autor:	Joanne B. Hart, Andrew Falshaw, Peter C. Tyler
Rok vydání:	2010
Předmět:	chemistry.chemical_compound chemistry Pinitol Stereochemistry Glycoside hydrolase Inositol General Medicine Quebrachitol Enantiomer Inhibitory postsynaptic potential Conduritol B-epoxide
Zdroj:	ChemInform. 32
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200107182
Popis:	The 1 d and 1 l enantiomers of 1,2-anhydro-myo-inositol (conduritol B epoxide) were synthesised from 1 d -pinitol and 1 l -quebrachitol, respectively, and their activities were compared in selected glycosidase inhibition assays. The 1 d enantiomer was found to be the active isomer, functioning as an irreversible inhibitor of sweet almond β- d -glucosidase. Neither isomer was active against the α- d -glucosidase from Bacillusstearothermophilus or the β- d -galactosidase from Aspergillusoryzae.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::17d26306c058894057eb0e0e948961d7 https://doi.org/10.1002/chin.200107182 Zobrazit plný text záznamu Plný text