Total Synthesis of Meayamycin and O-Acyl Analogues

Autor:	Prem B. Chanda, Gregory D. Vite, Naidu S. Chowdari, Christopher Gartshore, Dale L. Boger, Anindya Sarkar, Shinji Tadano, Qian Zhang, Jelena Momirov, Sanjeev Gangwar
Rok vydání:	2020
Předmět:	Stereochemistry Chemistry Longest linear sequence Meayamycin Organic Chemistry Total synthesis Physical and Theoretical Chemistry Biochemistry Divergent synthesis
Zdroj:	Organic Letters. 22:8714-8719
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.0c03308
Popis:	A short, scalable total synthesis of meayamycin is described by an approach that entails a longest linear sequence of 12 steps (22 steps overall) from commercially available chiral pool materials (ethyl l-lactate, BocNH-Thr-OH, and d-ribose) and introduces the most straightforward preparation of the right-hand subunit detailed to date. The use of the approach in the divergent synthesis of a representative series of O-acyl analogues is exemplified.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::17c615bc98bb2e36e870a5d2769f6bf1 https://doi.org/10.1021/acs.orglett.0c03308 Zobrazit plný text záznamu