The role of major apoptotic proteins in Ca2+ dependent cell homeostasis

Autor:	I. A. Kostanyan, E. V. Orlova, V. P. Panov
Rok vydání:	2005
Předmět:	Pharmacology Programmed cell death medicine.anatomical_structure Downregulation and upregulation Apoptosis Mechanism (biology) Drug Discovery Cell Pharmacology toxicology medicine Biology Homeostasis Cell biology
Zdroj:	Pharmaceutical Chemistry Journal. 39:621-626
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-006-0032-8
Popis:	The key role of Bcl-2 (B-cell lymphoma) family proteins in programmed cell death (apoptosis) is reliably established, but particular molecular mechanisms of downregulation involving these anti-and pro-apoptotic proteins are still insufficiently clear. There are several hypotheses explaining the cell-protective (Bcl-2, Bcl-XL) and pro-apoptotic (Bcl-x, Bak) functions of Bcl-2 family proteins. This paper briefly summarizes the available information concerning the molecular mechanisms of action of the pro-and anti-apoptotic proteins of Bcl-2 family. In particular, an original hypothesis is put forward according to which homo-and heterodimerization of these proteins are the key events in the mechanism of Ca2+ ion dependent homeostasis regulation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::17c5f0d110cc5764f23fcf6351a733b2 https://doi.org/10.1007/s11094-006-0032-8 Zobrazit plný text záznamu Plný text ve formátu PDF