ASSESSMENT OF THE DEMYELINATING PROCESS ACTIVITY IN PATIENTS WITH HERPESVIRAL MENINGITIS AND MENINGOENCEPHALITIS BASED ON THE LEVEL OF MYELIN BASIC PROTEIN (MBP) IN THE CEREBROSPINAL FLUID
| Autor: | Volodimir V. Pavlov, Larisa I. Markush, Yaroslava I. Burma, Hanna Spitsyna, Anton Sokhan, Liudmyla V. Kolesnyk, Oleksandr O. Goidenko |
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| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
medicine.medical_specialty biology medicine.diagnostic_test business.industry Meningoencephalitis Respiratory infection General Medicine medicine.disease Gastroenterology Myelin basic protein 03 medical and health sciences Meningismus 0302 clinical medicine Cerebrospinal fluid Immunoassay Internal medicine medicine biology.protein business Herpesviral meningitis Meningitis 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | Wiadomości Lekarskie. 74:512-516 |
| ISSN: | 0043-5147 |
| DOI: | 10.36740/wlek202103124 |
| Popis: | The aim: To study the peculiarities of demyelination by detection of changes in the levels of myelin basic protein (MBP) in CSF of patients with acute herpesviral meningitis (M) and meningoencephalitis (ME). Materials and methods: A total of 136 CSF samples from 68 patients with herpesviral M and ME were collected. The control group consisted of patients with acute respiratory infection and meningismus. MBP level in CSF was identified at the admission and after 10-12 days of treatment. Analysis of MBP concentrations in CSF was performed using an enzyme immunoassay. Results: Examination of patients on the first day of hospitalization showed the presence of a significant increase of MBP in the CSF in all patients with viral M/ME compared with the indicators of the comparison group (р0.05). Conclusions: The increase of MBP level identified in patients with acute M/ME confirms the presence of the demyelinating process that occurs in all patients, but it is more pronounced in patients with ME. |
| Databáze: | OpenAIRE |
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