Non-catalytic multicomponent rapid and efficient approach to 10-(2,4,6-trioxohexahydropyrimidin-5-yl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-xanthen-1-ones from salicylaldehydes, dimedone, and barbituric acids

Autor:	Tatiana A. Zaimovskaya, Olga O. Sokolova, Michail N. Elinson, Mikhail P. Egorov, Ruslan F. Nasybullin
Rok vydání:	2015
Předmět:	Green chemistry chemistry.chemical_compound Ethanol Chemistry Stereochemistry Dimedone General Chemistry Non catalytic Combinatorial chemistry Carbanion
Zdroj:	Monatshefte für Chemie - Chemical Monthly. 146:1689-1694
ISSN:	1434-4475 0026-9247
DOI:	10.1007/s00706-015-1512-x
Popis:	Non-catalytic multicomponent reaction of salicylaldehydes, dimedone, and barbituric acids initiated by reflux in ethanol results in the fast (5 min) and efficient formation of substituted tetrahydro-1H-xanthen-1-ones in 90–95 % yields. The developed fast multicomponent approach to the substituted tetrahydro-1H-xanthen-1-ones, which are known as medicinally relevant substances such as antibiotics, enzyme inhibitors, and anticancer drugs, is beneficial from the viewpoint of diversity-oriented multi-gram-scale processes and represents fast, efficient, and environmentally benign synthetic concept for multicomponent reaction strategy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::17c197140cabf86b65f7ade601b112fe https://doi.org/10.1007/s00706-015-1512-x Zobrazit plný text záznamu Full text from SpringerLink