A Study of the Effect of Antiserum on Poliovirus Infection Induced by the Intraspinal Inoculation of Rhesus Monkeys
| Autor: | Oscar C. Liu, Joseph E. Carter, Armand N. DeSanctis, John A. Geating, Bettylee Hampil |
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| Rok vydání: | 1958 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 80:106-113 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.80.2.106 |
| Popis: | Summary After intraspinal inoculation of the Mahoney strain of poliovirus into rhesus monkeys, the central nervous systems from a number of animals were dissected out at various intervals. TCID50 titrations, histologic examination of such obtained tissues, and clinical observation of the infected animals indicated that the poliovirus spread from cell to cell in the gray matter of the CNS, following a pattern of anatomic contiguity rather than along the nerve fibers. Intravenous administration of specific antiserum into such infected monkeys, immediately following infection and 24- to 48-hr postinfection, reduced the mortality from 75 to 100% down to 0%. The extent of muscles paralyzed also was reduced significantly by the treatment as compared with the corresponding controls. In the treated groups there is a tendency that the more delayed the treatment, the wider the involvement of the skeletal muscles. |
| Databáze: | OpenAIRE |
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