Notch1 Signaling Regulates Wound Healing via Changing the Characteristics of Epidermal Stem Cells
| Autor: | Shao-Hai Qi, Ying-Bin Xu, Yan Shi, Ronghua Yang, Xu-Sheng Liu, Julin Xie, Peng Wang, Bin Shu, Jian Liu |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
integumentary system Regeneration (biology) Notch signaling pathway Regulator Biology Bioinformatics Cell biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Dermis Downregulation and upregulation 030220 oncology & carcinogenesis embryonic structures medicine biological phenomena cell phenomena and immunity Stem cell Signal transduction Wound healing |
| Zdroj: | Journal of Stem Cell Research & Therapy. 6 |
| ISSN: | 2157-7633 |
| DOI: | 10.4172/2157-7633.1000348 |
| Popis: | During wound healing and reconstruction, epidermal stem cells (ESCs) migrate to the wound site and activate to repair the damaged epithelium. Moreover, there exist complicate signaling pathways to regulate wound regeneration including Notch signaling. The Notch signaling pathway is a regulator of epidermal differentiation, which may be an important mediator of wound regeneration that participates in various processes, from the development of the dermis to the formation of skin appendages. Here, we show that Notch signaling pathways are upregulated by Jagged1 in ESCs and stem cell characteristics of ESCs change when Notch1 signaling varies. By administration of siRNAJagged1 knockdown ESCs in wounds, we observe that the suppression of Jagged1 down regulate expression of Notch signaling and resulted in poor-quality wound healing. Connecting Notch1 pathways activity to ESCs response to wound repairing may develop a new therapeutic strategy for delayed healing. |
| Databáze: | OpenAIRE |
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