Abstract P1-10-02: Comparative Preventive Efficacy of Select Chinese Herbs in Breast Carcinoma Derived Isogenic Cells with Modulated Estrogen Receptor Functions

Autor:	Nitin T. Telang, Daniel W. Sepkovic, Gyc Wong, G Li, HL Bradlow, Meena Katdare
Rok vydání:	2012
Předmět:	Cancer Research Estrogen receptor Cancer Pharmacology Biology medicine.disease Phenotype In vitro chemistry.chemical_compound Oncology chemistry In vivo Apoptosis medicine Growth inhibition Transcription factor
Zdroj:	Cancer Research. 72:P1-10
ISSN:	1538-7445 0008-5472
DOI:	10.1158/0008-5472.sabcs12-p1-10-02
Popis:	Background: Human mammary carcinoma derived estrogen receptor positive (ER+) MCF-7 cells depend on 17β-estradiol (E2) for cellular proliferation in vitro and for tumor development in vivo. Traditionally, ER functions as a ligand activated nuclear transcription factor with E2 as its physiological ligand, and limited availability of E2 modulates ER functions. We have recently demonstrated preventive efficacy of selected Chinese nutritional herbs in this MCF-7 cell culture model. The present study screened additional Chinese nutritional herbs for their preferential preventive efficacy on MCF-7 cells with modulated ER functions. Methods: MCF-7 cells were maintained in medium supplemented with either 0.7% serum, Conclusions: Preferential growth inhibition by Chinese nutritional herbs in isogenic ER-NF and ER-F phenotypes of MCF-7 cells and mechanistic efficacy of representative herbs identify possible leads towards their rapid prioritization for planning prevention trials on ER+ and ER− clinical breast cancer. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P1-10-02.
Databáze:	OpenAIRE
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