Efficacy of a bivalent inactivated vaccine against red seabream iridovirus and Streptococcus iniae in red seabream, Pagrus major
| Autor: | Hidenori Miyadai, Ayana Murakami, Shiori Tsubone, Kittipong Thanasaksiri, Murakami Taiga, Ryoko Takano, Kohei Fukuda |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
business.industry Outbreak Aquatic animal 04 agricultural and veterinary sciences Aquatic Science Biology biology.organism_classification Bivalent (genetics) Microbiology Vaccination Pagrus major 03 medical and health sciences 030104 developmental biology Aquaculture Inactivated vaccine 040102 fisheries 0401 agriculture forestry and fisheries Streptococcus iniae business |
| Zdroj: | Aquaculture. 492:132-136 |
| ISSN: | 0044-8486 |
| Popis: | The red seabream (Pagrus major) is an economically important marine fish species that is cultured in Japan. Natural outbreaks of red seabream iridovirus (RSIV) and/or Streptococcus iniae can cause massive mortalities and severe economic losses in red seabream production. No effective single-injection vaccine for protecting red seabream against both diseases has yet become commercially available. Here, we evaluated the efficacy of a bivalent formalin-killed vaccine (PISCIVAC™ Irido Si) against RSIV and S. iniae infections in red seabream. In laboratory trials, intraperitoneally vaccinated fish reared at 25 °C were protected against challenges with RSIV and S. iniae as early as 3 days post vaccination (dpv), with a relative percent survival (RPS) of 69% and 90%, respectively. The protection was also observed in fish reared at 15 °C, with a RPS of 88% and 89% after challenging the fish with RSIV and S. iniae at 10 dpv and 14 dpv, respectively. Furthermore, intramuscular vaccination effectively protected fish against RSIV (RPS of 100% and 65–96% at 10 and 20 dpv, respectively) and S. iniae (RPS of 92–100% at 14 dpv). The vaccine conferred protection against RSIV infection for at least 2 months and against S. iniae infection for at least 6 months in the field trial. These results indicate that PISCIVAC™ Irido Si is effective for protecting red seabream against RSIV and S. iniae infections. |
| Databáze: | OpenAIRE |
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