Neurotensin receptor binding and antinociceptive activity for lipophilic Nα-amido neurotensin(9–13) analogs
| Autor: | Gary A. Cain, Alexander L. Johnson, Pat N. Confalone, Richard S. Pottorf, S. William Tam, William K. Schmidt, Thomas E. Christos |
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| Rok vydání: | 1993 |
| Předmět: |
Stereochemistry
Chemistry digestive oral and skin physiology Organic Chemistry Clinical Biochemistry Analgesic Pharmaceutical Science Neuropeptide Peptide hormone complex mixtures Biochemistry Chemical synthesis chemistry.chemical_compound Nociception In vivo Drug Discovery Molecular Medicine Molecular Biology hormones hormone substitutes and hormone antagonists Neurotensin Neurotensin receptor binding |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 3:2055-2060 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(01)81014-3 |
| Popis: | A series of lipophilic Nα-amido-neurotensin(9–13) analogs was prepared. These acylated pentapeptides exhibited good neurotensin receptor binding, as well as in vivo analgesic activity via i.c.v. and even intravenous routes of administration. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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