Novel Dimethyltyrosine–Tetrahydroisoquinoline Peptidomimetics with Aromatic Tetrahydroisoquinoline Substitutions Show in Vitro Kappa and Mu Opioid Receptor Agonism
| Autor: | Traynor, Deanna Montgomery, Hartman Jg, Henry I. Mosberg, Sánchez-Santiago Aa, Nicholas W. Griggs, Jessica P. Anand, Thomas J Fernandez, Irina D. Pogozheva |
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| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
Physiology Tetrahydroisoquinoline Peptidomimetic Stereochemistry Cognitive Neuroscience Multifunctional ligands Cell Biology General Medicine Biochemistry In vitro δ-opioid receptor 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry μ-opioid receptor 030217 neurology & neurosurgery Kappa 030304 developmental biology |
| Zdroj: | ACS Chemical Neuroscience. 10:3682-3689 |
| ISSN: | 1948-7193 |
| DOI: | 10.1021/acschemneuro.9b00250 |
| Popis: | The dimethyltyrosine–tetrahydroisoquinoline (Dmt-Tiq) scaffold was originally developed in the production of selective delta opioid receptor (DOR) antagonists. Installation of a 7-benzyl pendant on... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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