Early-pregnancy changes in cardiac diastolic function in women with recurrent pre-eclampsia and in previously pre-eclamptic women without recurrent disease

Autor: Arnold J. Kruse, Luc J.M. Smits, Louis L.H. Peeters, Sebastiaan C.A.M. Bekkers, Simone J. S. Sep, M. P. H. Schreurs
Rok vydání: 2011
Předmět:
Zdroj: BJOG: An International Journal of Obstetrics & Gynaecology. 118:1112-1119
ISSN: 1470-0328
DOI: 10.1111/j.1471-0528.2011.02951.x
Popis: Please cite this paper as: Sep S, Schreurs M, Bekkers S, Kruse A, Smits L, Peeters L. Early-pregnancy changes in cardiac diastolic function in women with recurrent pre-eclampsia and in previously pre-eclamptic women without recurrent disease. BJOG 2011;118:1112–1119. Objective To compare early-pregnancy changes in cardiac diastolic function between formerly pre-eclamptic women with (RECUR) and without (NORECUR) recurrent pre-eclampsia. Design Retrospective observational cohort study. Setting Tertiary referral centre. Population Pregnant women with a history of early-onset pre-eclampsia (n = 34). Methods The peak mitral filling velocity in early diastole (E) and at atrial contraction (A), and the E/A ratio were assessed before and at 12, 16 and 20 weeks of gestation in the next pregnancy. Differences in early-pregnancy alterations between women with (RECUR) and without (NORECUR) recurrent pre-eclampsia were evaluated by use of mixed design analysis of covariance. Main outcome measures Cardiac function and recurrent pre-eclampsia. Results In ten women (29%) pre-eclampsia recurred. By 12 weeks of gestation the E/A ratio had increased in the RECUR group, but not in the NORECUR group (P
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