Synthesis and Phytotoxic Evaluation of 3-Indolylglycine Derivatives as New Natural-Like Herbicides
| Autor: | Alexandra Amaral, Julia Willig, Conceição Olguin, Isadora Oliveira, Helio Stefani, Giancarlo Botteselle, Flávia Manarin |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Journal of the Brazilian Chemical Society. |
| ISSN: | 1678-4790 0103-5053 |
| DOI: | 10.21577/0103-5053.20230058 |
| Popis: | A novel class of potential herbicides, 3-indolylglycines were synthesized using an effective, green and rapid approach via multicomponent reaction (aza-Friedel-Crafts) between indoles, aldehydes and anilines in a water/sodium dodecyl sulfate system. The main advantages of this methodology are ease of handling, scalable to gram scale and a metal-free approach. The reaction is compatible with a variety of functional groups, obtaining the desired products in moderate to excellent yields. The biological activity of the 3-indolylglycines was evaluated, and it was found that these compounds interfere with the germination and radicle growth of Lactuca sativa, mainly the compound 4k. |
| Databáze: | OpenAIRE |
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