Topical MAL-PDT for cervical intraepithelial neoplasia treatment: a non-surgical option to prevent a cervical cancer

Autor: Cristina Kurachi, Fernanda Mansano Carbinatto, Jose Roberto Trujillo, Welington Lombardi, Natália Fernandez Cossetin, Natalia Mayumi Inada, Vanderlei Salvador Bagnato
Rok vydání: 2015
Předmět:
Zdroj: Photodiagnosis and Photodynamic Therapy. 12:370
ISSN: 1572-1000
DOI: 10.1016/j.pdpdt.2015.07.202
Popis: Cervical cancer is the third most commonly diagnosed cancer and the fourth leading cause of cancer death in womenworldwide. The highest incidence rates are in Africa, as well as South-Central Asia and South America. According to the National Institute of Cancer (INCA) at the last year, it was estimated 15,590 new cases of cervical cancer in Brazil. About 90% of cervical cancers originate in the evolution of cervical intraepithelial neoplasia (CIN) which is classified on the basis of cyto-histological characteristics (low and high grade lesions). The equipment (CerCa 150 System, MMOptics Ltda., Trubios LLC, Brazil-USA) and the medication (20% MAL cream, PDTPharma, Brazil) are produced in Brazil with relative low cost. The Photodynamic Therapy is a promising procedure and it is even known as safe to normal tissue. The device includes two components specifically adapted to detect and treat abnormal cervical tissue, enabling proper lighting of the cervix. It is portable and does not require special infrastructure or installation. More than 60 patients between the ages of 14-57 years and with CIN 1 were treated and presented 100% of cure. Based on these results a larger randomized study with patients with CIN 2, placebo and follow-up only is ongoing.
Databáze: OpenAIRE
Externí odkaz: