Comparative efficacy of betamethasone/clioquinol (Betnovate-C) cream and betamethasone/fusidic acid (Fucibet) cream in the treatment of infected hand eczema

Autor:	E. Wong, M. F. Corbett, A. P. Menday, V. A. Hill
Rok vydání:	1998
Předmět:	medicine.medical_specialty business.industry medicine.drug_class Fusidic acid Clioquinol Dermatology Betamethasone valerate chemistry.chemical_compound Tolerability chemistry Toxicity Medicine Corticosteroid Betamethasone business medicine.drug Antibacterial agent
Zdroj:	Journal of Dermatological Treatment. 9:15-19
ISSN:	1471-1753 0954-6634
DOI:	10.3109/09546639809160683
Popis:	The efficacy, tolerability and acceptability of betamethasone valerate 0.1%/fusidic acid 2% cream and betamethasone valerate 0.1%/clioquinol 3% cream were compared in 120 patients of either sex, aged 18 years or over, with a clinical diagnosis of infected hand eczema. Both creams were applied twice daily for up to 4 weeks. Assessments were made by the investigator and by the patient at baseline and at 1, 2 and 4 weeks. Swabs were taken for bacteriological culture at baseline and at the end of treatment. Overall, both creams were similarly effective clinically, with 57.9% of patients given betamethasone/clioquinol and 60.4% of patients given betamethasone/fusidic acid responding (NS; 95% confidence interval for difference -16.1, 21.2). However, betamethasone/fusidic acid cream gave a significantly better bacteriological response (P< 0.005). Both treatments were well tolerated. Betamethasone/fusidic acid cream was considered by the patients to be a significantly more cosmetically acceptable treatment (P
Databáze:	OpenAIRE
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