Follicular and endocrine dose responses according to anti‐Müllerian hormone levels in IVF patients treated with a novel human recombinant FSH ( FE 999049)
| Autor: | Ernesto Bosch, Bernadette Mannaerts, Pedro N. Barri, Manuel Fernández-Sánchez, Juan A. Garcia-Velasco, Joan-Carles Arce, Petra De Sutter, Bjarke Mirner Klein, Hana Visnova, Anders Nyboe Andersen |
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| Rok vydání: | 2015 |
| Předmět: |
endocrine system
medicine.medical_specialty In vitro fertilisation urogenital system Endocrinology Diabetes and Metabolism medicine.medical_treatment Anti-Müllerian hormone Biology Intracytoplasmic sperm injection Endocrinology Human fertilization Internal medicine Follicular phase medicine biology.protein Endocrine system Population study hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Clinical Endocrinology. 83:902-912 |
| ISSN: | 1365-2265 0300-0664 |
| Popis: | SummaryObjective To study the association between serum anti-Mullerian hormone (AMH) levels and follicular development and endocrine responses induced by increasing doses (5·2–12·1μg/day) of a novel recombinant human FSH (rhFSH, FE 999049) in patients undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) in a GnRH antagonist protocol. Design Secondary analysis of a randomized controlled trial with stratified randomization according to AMH (lower stratum: 5·0–14·9 pmol/l; higher stratum: 15·0–44·9 pmol/l). Patients Infertile women of good prognosis (n = 265). Measurements Follicular development and endocrine parameters during controlled ovarian stimulation (COS) with rhFSH. Results Serum FSH levels increased with increasing rhFSH doses and steady-state levels for each dose were similar in both AMH strata. In the whole study population, significant (P |
| Databáze: | OpenAIRE |
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