| Autor: |
Molly B. Reilly, Cyril Cros, Marc Hammarlund, Seth R. Taylor, Alec Barrett, Gabriel Santpere, Saeed Tavazoie, Alexander J. Abrams, Abigail Poff, Lori Glenwinkel, Manasa Basavaraju, Oliver Hobert, Chuan Xu, Erdem Varol, David M. Miller, Eviatar Yemini, Rebecca McWhirter, Panos Oikonomou, Nenad Sestan, Berta Vidal, Ibnul Rafi, Steven J. Cook, Alexis Weinreb |
| Rok vydání: |
2020 |
| Předmět: |
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| Popis: |
SummaryNervous systems are constructed from a deep repertoire of neuron types but the underlying gene expression programs that specify individual neuron identities are poorly understood. To address this deficit, we have produced an expression profile of all 302 neurons of theC. elegansnervous system that matches the single cell resolution of its anatomy and wiring diagram. Our results suggest that individual neuron classes can be solely identified by combinatorial expression of specific gene families. For example, each neuron class expresses unique codes of ∼23 neuropeptide-encoding genes and ∼36 neuropeptide receptors thus pointing to an expansive “wireless” signaling network. To demonstrate the utility of this uniquely comprehensive gene expression catalog, we used computational approaches to (1) identify cis-regulatory elements for neuron-specific gene expression across the nervous system and (2) reveal adhesion proteins with potential roles in synaptic specificity and process placement. These data are available at cengen.org and can be interrogated at the web application CengenApp. We expect that this neuron-specific directory of gene expression will spur investigations of underlying mechanisms that define anatomy, connectivity and function throughout theC. elegansnervous system. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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