Antiatherosclerotic properties of 4-(2,6-dimethylheptyl)-and 4-(2,6,10-trimethylundecyl)benzoic acids and their amides

Autor:	V. V. Tertov, L. V. Filatova, Edward P. Serebryakov, G. V. Kryshtal, Alexander N. Orekhov, Galina M. Zhdankina
Rok vydání:	2006
Předmět:	Pharmacology chemistry.chemical_classification Cholesterol Stereochemistry In vitro chemistry.chemical_compound Hydrolysis chemistry Polyol Cell culture Amide Drug Discovery Protein biosynthesis Benzoic acid
Zdroj:	Pharmaceutical Chemistry Journal. 40:639-644
ISSN:	1573-9031 0091-150X
Popis:	Two amides with polyol-rich moieties and two other analogs with N-(β-aminoethyl)amide groups, all derived from 4-(2,6-dimethylheptyl)benzoic acid (I), and two polyol amides derived from 4-(2,6,10)-trimetylundecyl) benzoic acid (II) were synthesized and tested for antiatherosclerotic activity in vitro. None of the amides prevented excessive accumulation of cholesterol in the culture of smooth muscle cells (SMCs) raised from human aorta sclerotic plaque, although polyol amides from acid I inhibited protein synthesis in this cell culture. In human liver homogenates (HLHs) all amides derived from acid I accelerated the human cholesterol esterase-catalyzed hydrolysis of cholesteryl palmitate. Acid I displayed antiatherosclerotic effects in both SMC and HLH assays, while acid II and its amides were ineffective in either of these test systems.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::17803e67862d5f4bf627f64796a5e76e https://doi.org/10.1007/s11094-006-0210-8 Zobrazit plný text záznamu Plný text ve formátu PDF