| Autor: |
Jean-Pierre Liautard, Jean Pierre Liautard, Antoine Gross, F. Ottones, F. Rabenoelina, Jean Favero |
| Rok vydání: |
2000 |
| Předmět: |
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| Zdroj: |
Immunology. 100:252-258 |
| ISSN: |
0019-2805 |
| Popis: |
Human gamma delta T cells are considered to play an important role in the early response to infection with intracellular pathogens. Evidence has been presented that the percentage of gamma delta T cells with Vgamma9Vdelta2 phenotype is dramatically increased in the peripheral blood of patients with acute brucellosis. This specific gd T-cell subpopulation is known to be activated by small non-peptidic molecules that can either be produced by the pathogen itself or released from damaged cells after infection. In the present work we provide evidence that Vgamma9Vdelta2 T lymphocytes from peripheral blood mononuclear cells of healthy donors can be specifically activated by non-peptidic low-molecular-weight compound(s) from Brucella suis lysate. Moreover, we show that Vgamma9Vdelta2 T cells activated by this B. suis fraction produce tumour necrosis factor-alpha and interferon-gamma, which reduce bacterial multiplication inside infected cells. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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