Thermal Amination of 2,6-Dihalopyridines by Sterically Demanding Amines

Autor:	Andreas Faust, Oliver Wolff, Siegfried R. Waldvogel
Rok vydání:	2008
Předmět:	chemistry.chemical_classification Steric effects Base (chemistry) chemistry Acid labile Organic Chemistry Combinatorial chemistry Catalysis Amination
Zdroj:	Synthesis. 2009:155-159
ISSN:	1437-210X 0039-7881
DOI:	10.1055/s-0028-1083268
Popis:	When transition-metal-catalyzed transformations fail, the aminationreaction of activated bromo- and chloropyridines can be achievedthermally. The auxiliary base 2,2,6,6-tetramethylpiperidine turnedout to be the key for the conversion of highly sterically demandingand acid labile amines.
Databáze:	OpenAIRE
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