Elimination of carbon monoxide by electron impact on quinolineN-oxide, carbostyril and 8-hydroxyquinoline

Autor:	Quentin N. Porter, Li Li Yeoh, Richard G. Gillis, Thomas Blumenthal
Rok vydání:	1991
Předmět:	Indole test Flash vacuum pyrolysis Quinoline 8-Hydroxyquinoline Mass spectrometry Biochemistry Medicinal chemistry chemistry.chemical_compound chemistry Molecular Medicine Organic chemistry Isoquinoline Instrumentation Spectroscopy Electron ionization Carbon monoxide
Zdroj:	Organic Mass Spectrometry. 26:247-249
ISSN:	1096-9888 0030-493X
DOI:	10.1002/oms.1210260412
Popis:	Under electron impact, the molecular ions of quinoline N-oxide, carbostyril and 8-hydroxyquinoline lose carbon monoxide giving a fragment ion C8H7N (m/z 117), which was shown by collision-activated dissociation in each case to have the structure of the molecular ion of indole. Its formation from 8-hydroxyquinoline requires an unusual rearrangement. Isoquinoline N-oxide loses HCN rather than CO and gives a fragment which has the structure of the molecular ion of benzofuran. When the first three compounds were subjected to flash vacuum pyrolysis, quinoline N-oxide at 500–700°C gave carbostyril and indole was detected by gas chromatography/mass Spectrometry. At 900°C carbostyril and 8-hydroxyquinoline both gave indole in small amounts, detected by gas chromatography/mass Spectrometry.
Databáze:	OpenAIRE
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