ChemInform Abstract: Stereoselective Synthesis of Dibenzoxapine Containing Tetrasubstituted Exocyclic Alkenes via Cascade Methylboronic Acid Coupling Reactions

Autor:	Marta Adeva, Matthew W. Carson, Hannah Yu, Scott A. May, Carmen Somoza, Rachel N. Richey, Michael J. Coghlan, Javier Mendiola
Rok vydání:	2008
Předmět:	Methylboronic acid Stereochemistry Chemistry Intramolecular force Stereoselectivity General Medicine Coupling reaction
Zdroj:	ChemInform. 39
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200826178
Popis:	A stereoselective method for the preparation of dibenzoxapine containing tetrasubstituted exocyclic E-alkenes has been developed. The key reaction involves an intramolecular cyclocarbopalladation of alkynes to form a vinylpalladium species and subsequently coupling the vinylpalladium with methylboronic acid. The approach provides a straightforward method for the synthesis of tetrasubstituted exocyclic E-alkenes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::176ba1ccf93b5951211e8668d7909061 https://doi.org/10.1002/chin.200826178 Zobrazit plný text záznamu Plný text