Randomisierte Studie zur Methotrexatapplikation in der Erhaltungstherapie der akuten lymphoblastischen Leukämie im Kindesalter*

Autor:	Jobke A, Jacobi H, Lasson U, Schenck W, Langermann Hj, Streitberger W, Imm W, Nawrath H, Hofweber K, Gutjahr P, G Nessler, H. Wehinger
Rok vydání:	1982
Předmět:	medicine.medical_specialty Regimen Leukemia Every Two Weeks business.industry Internal medicine Pediatrics Perinatology and Child Health medicine Complete remission medicine.disease business Gastroenterology
Zdroj:	Klinische Pädiatrie. 194:214-218
ISSN:	1439-3824 0300-8630
DOI:	10.1055/s-2008-1033808
Popis:	58 children were admitted to a prospective randomized leukemia induction and CNS-prophylaxis three different protocols were followed for maintenance. A (n = 20): 6-MP (50 mg/m2) p.o. daily + MTX (20-30 mg/m2) p.o. weekly; B (n = 20): 6-MP (50 mg/m2) p.o. daily + MTX (75-150 mg/m2) i.v. every two weeks; C (n = 18): 6-MP (50 mg/m2) p.o. daily + alternating 8-week-courses of four biweekly i.v. injections of MTX (75-150 mg/m2) and four biweekly i.v. injections of Cyclo (600 mg/m2). After all patients have been followed for at least 48 months, the rates of continuous complete remission are 42% in protocol A, 63% in protocol B, and 29% in protocol C. No encephalopathies have been observed with regimen B.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1766fddde6020fcd25b9518e59fb1eb4 https://doi.org/10.1055/s-2008-1033808 Zobrazit plný text záznamu