Unusual familial lipoprotein C-III associated with apolipoprotein C-III-0 preponderance
| Autor: | Hideo Maeda, Ritsu Kamei, Haruo Uzawa |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Apolipoprotein E
medicine.medical_specialty Very low-density lipoprotein Apolipoprotein B biology Biophysics Apolipoprotein C-III Biochemistry chemistry.chemical_compound Endocrinology chemistry Internal medicine Low-density lipoprotein medicine biology.protein lipids (amino acids peptides and proteins) Lipoprotein disorder Apolipoprotein C2 Lipoprotein |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 665:578-585 |
| ISSN: | 0005-2760 |
| DOI: | 10.1016/0005-2760(81)90273-3 |
| Popis: | Among 256 consecutive subjects so far studied in our laboratory, we found one subject (a 63-year-old female) whose very low density lipoprotein (VLDL) and high density lipoprotein (HDL) contained unusually high amounts of apolipoprotein C-III-0 among apolipoprotein C-III polymorphic forms. Identification of apolipoprotein C-III-0 was achieved by a combination of basic polyacrylamide gel electrophoresis, isoelectric focusing and sialidase treatment of plasma apolipoproteins. This unusual lipoprotein was inherited by two of her four children without the manifestation of clinical symptoms. Triacylglycerols and cholesterol concentrations of VLDL, low density lipoprotein (LDL) and HDL fractions, and serum apolipoprotein C-III levels of the three subjects with apolipoprotein C-III-0 were within the normal range, as estimated by rocket immunoelectrophoresis. Our results clearly demonstrated that the unusual lipoproteins with the preponderance of apolipoprotein C-III-0 among apolipoprotein C-III polymorphic forms were genetically determined. These cases may be a new type of genetic lipoprotein disorder. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|