Superelectrophilic Csp3–H bond fluorination of aliphatic amines in superacid: the striking role of ammonium–carbenium dications

Autor:	Agnès Martin-Mingot, Sébastien Thibaudeau, M. Artault, Naima Mokhtari, Thomas Cantin
Rok vydání:	2020
Předmět:	Hydrogen bond Metals and Alloys General Chemistry Medicinal chemistry Catalysis Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry.chemical_compound chemistry Electrophile Materials Chemistry Ceramics and Composites Ammonium Superacid
Zdroj:	Chemical Communications. 56:5905-5908
ISSN:	1364-548X 1359-7345
DOI:	10.1039/d0cc02081h
Popis:	The superacid-promoted electrophilic Csp3–H bond activation of aliphatic amines generates superelectrophilic species that can be subsequently fluorinated. Demonstrated by low-temperature in situ NMR experiments, the ammonium–carbenium dications, crucial for this reaction, can also react with C–H bonds opening future synthesis perspectives for this mode of activation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::175a468ad2946a89993eda22c63712c2 https://doi.org/10.1039/d0cc02081h Zobrazit plný text záznamu