Erlotinib in Second and Third Line Therapy in Advanced NSCLC (Stage IIIB and IV), Relation with Chemotherapy and Schedule of Administration (A Retrospective Study)

Autor: S.E. Boeru, A. Grigorescu, I. Turtoi
Rok vydání: 2012
Předmět:
Zdroj: Annals of Oncology. 23:ix398
ISSN: 0923-7534
Popis: Background Is now very well known that Erlotinib (E) has an impact in progression free survival and in some study in overall survival in second or third line therapy for advanced non small -cell lung cancer (NSCLC). Aims of the study: This study try to provide data which sustain the use of E in second and third line and the fact that mono-chemotherapy could be active and after treatment with E for some patients (Pt) with advanced NSCLC. In addition we try to find data supporting the use of E for senior adults. Materials and method The data from 90 case report forms of Ps with Stage IIIB and IV NSCLC treated with E in Institute of Oncology Bucharest between March 2010 and March 2012 were analyzed regarding clinical benefit, survival and relation with mono- chemotherapy in second or third line. In particular we purposed to point out the benefit of senior adults treated with E and the possible benefit of chemotherapy with a single agent after failure of treatment with E. Main symptoms were evaluated by Edmonton scale. Statistical analysis was perform by Caplan Meyer curve and X2 test. Results 86 Pt were valuable, 17 with stage IIIB and 69 stage IV. The overall survival for the Pt included in this study was 17 month. The survival in second line therapy with E was 7 month (CI: 3.6 – 10.3) and the survival after third line chemotherapy was 3 month (CI:2.1-3.8). On the whole the clinical benefit was 90% of Pt. The response rate for chemotherapy in third line after E was 8% but symptomatic benefit was in 15% of Pt. As a function of waiting time to receive E in second line it was a higher response rate in Ps who received E without waiting time, toxicity of E was represented by rash grade I 80%, diarrhea 10%, dizziness 3%, ocular dysfunctions 2%. Grade III of toxicity was observed only in 3% of patients. Toxicity for senior adults treated by E. was similar with younger Pt. Conclusions Despite the limits of a retrospective study we can conclude that E is useful in second and third line treatment for advanced lung cancer, chemotherapy could have benefit in third line after E, and senior adults have about the some response and benefit from E. Toxicity was reduced for all Pt treated with E. Disclosure All authors have declared no conflicts of interest.
Databáze: OpenAIRE
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