Correlation between LC50 for Adult Fish and Fish Embryos

Autor:	K. V. Nakhod, K. V. Zolotarev, A. N. Mikhailov, M. V. Mikhailova
Rok vydání:	2017
Předmět:	0301 basic medicine Correlation Partition coefficient 03 medical and health sciences 030104 developmental biology Correlation coefficient Chemistry Fish General Medicine Common logarithm Food science General Biochemistry Genetics and Molecular Biology
Zdroj:	Bulletin of Experimental Biology and Medicine. 163:749-752
ISSN:	1573-8221 0007-4888
Popis:	Testing for substance toxicity for living organisms is an important step in the development and adaptation of new drugs for various purposes. Analysis of the dependences between toxicological parameters of chemical substances for various test objects and physicochemical properties of these agents is a promising trend. Partition coefficient logP (logKow) was chosen as the key physicochemical parameter determining the toxicological parameters of the same substance for hydrobionts at different developmental stages. We found a correlation between decimal logarithm of the ratio of LCe 50 for fish embryos to LCa 50 for adult fish and logP. This dependence was found as a liner combination of equations obtained by drawing a trend line between experimental points and calculation of Pearson’s correlation coefficient R.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::173caf3089047d051762c9f8af6bb07f https://doi.org/10.1007/s10517-017-3895-7 Zobrazit plný text záznamu Full text from SpringerLink