| Autor: |
H. Siddaramaiah, Praveen Sivadasu, S. Hemalatha, D. V. Gowda |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
International Journal of Applied Pharmaceutics. :31-41 |
| ISSN: |
0975-7058 |
| DOI: |
10.22159/ijap.2020v12i1.35683 |
| Popis: |
Objective: The present study was an attempt to systemically deliver the most desirable schizophrenia drug, ziprasidone hydrochloride (ZRS) via the intranasal route using nanostructured lipid carrier (NLC) approach. Methods: The desired ZRS loaded NLCs were developed using central composite statistical design and the developed formulation was monitored for improving ZRS bioavailability and their brain targeting efficacy. Results: Pharmacokinetic studies revealed a 10 fold increase (ZRS blood-brain ratio) for NLCs administered through nasal route (in comparison to intravenous route). Similarly, the concentration of ZRS (in the brain) delivered via nasal route exhibits 4 fold increment at all-time points. Conclusion: Therefore, the obtained results suggest a potential nose to brain transport of loaded ZRS by effective bypassing of the Blood-Brain Barrier (BBB). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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