| Autor: |
Guido Verniest, Riccardo Surmont, Peter ten Holte, Jan Willem Thuring, Norbert De Kimpe, Frederik Deroose, Mathias De Schrijver |
| Rok vydání: |
2011 |
| Předmět: |
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| Zdroj: |
ChemInform. 42 |
| ISSN: |
0931-7597 |
| DOI: |
10.1002/chin.201136119 |
| Popis: |
Fluorinated pyrazoles bearing additional functional groups that allow further functionalization are of considerable interest as building blocks in medicinal chemistry. The developed synthetic strategy for new 3-amino-4-fluoropyrazoles consists of a monofluorination of β-methylthio-β-enaminoketones using 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) (Selectfluor) toward the corresponding monofluorinated enaminoketones, followed by condensation with different hydrazines. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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