Atypical antidepressants: Effect of synaptosomal uptake of serotonin and GABA

Autor:	N. A. Avdulov, N. I. Maisov
Rok vydání:	1981
Předmět:	Atypical Antidepressants Chemistry General Medicine Serotonin Pharmacology Rat brain General Biochemistry Genetics and Molecular Biology
Zdroj:	Bulletin of Experimental Biology and Medicine. 92:1520-1522
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf00829889
Popis:	Effect of the antidepressants of different chemical groups--imipramine, desmethylimipramine, chlorimipramine, befuralin, trazodon, pyrazidol, inkasan and azaphen--on the uptake of 3H-serotonin and 3H-GABA by the crude synaptosomal fraction of the rat brain was studied. The Cm values for the uptake of serotonin and GABA were 0.195 and 30 micro M, respectively. Inkasan and azaphen were the most potent inhibitors of the 3H-serotonin uptake (65-70% inhibition at a concentration of 50 micro M. Azaphen and chlorimipramine were the only ones to inhibit the uptake of 3H-GABA at a concentration of 50 micro M. The majority of the antidepressants studied inhibited the GABA uptake only at high concentrations.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::172e8c66aa707955bcec9f177c3378f0 https://doi.org/10.1007/bf00829889 Zobrazit plný text záznamu Full text from SpringerLink