Two ways to skin a cat: acyldepsipeptides antibiotics can kill bacteria through activation or inhibition of ClpP activity
| Autor: | Robert H. Vass, Peter Chien |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification Proteases Protease biology medicine.diagnostic_test medicine.drug_class medicine.medical_treatment Proteolysis Antibiotics biology.organism_classification Microbiology Acyldepsipeptide antibiotics Mycobacterium tuberculosis 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology Enzyme chemistry medicine Molecular Biology Bacteria |
| Zdroj: | Molecular Microbiology. 101:183-185 |
| ISSN: | 0950-382X |
| DOI: | 10.1111/mmi.13382 |
| Popis: | Infection by Mycobacterium tuberculosis (Mtb) has had a devastating effect on the world population. Acyldepsipeptide antibiotics (ADEPs) are known to kill some bacteria by over activating the bacterial ClpP peptidase. ADEP antibiotics also target Mtb, with the assumption that uncontrolled ADEP-activated proteolysis by ClpP is the common mode of killing. In this issue of Molecular Microbiology, Famulla, et al. now show that ADEP's effectiveness in mycobacteria is likely due to inhibition of ClpP-dependent protease activity rather than activation. This finding of how the same antibiotic can kill bacteria by either inhibiting or activating proteases illustrates the utility of targeting these enzymes for sorely needed new antibiotics. |
| Databáze: | OpenAIRE |
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