Functionalization of 3-Chlorobenzaldehyde

Autor:	Torbjörn Lundstedt, Per Lek, Peteris Trapencieris, Sergey Belyakov, Arne Boman, Kristine Aksjonova, Edvards Liepinsh
Rok vydání:	2012
Předmět:	Nucleophile Chemistry Reagent Organic Chemistry Polymer chemistry Surface modification Organic chemistry Ring (chemistry) Tautomer Catalysis Quaternary carbon
Zdroj:	Synthesis. 44:2200-2208
ISSN:	1437-210X 0039-7881
DOI:	10.1055/s-0031-1289784
Popis:	2-Substituted 3-chlorobenzaldehydes were prepared from the corresponding 2-(3-chlorophenyl)-1,3-dioxolanes using an ortho-lithiation strategy. The 6-chloro-2-formylbenzamide exists only in a ring form, but 6-chloro-2-formylbenzoic acid esters were isolated in both forms as open chain and cyclic tautomers. 7-Chloro-3-hydroxy-3H-isobenzofuran-1-one reacted with nucleophilic reagents at the carbonyl or quaternary carbon depending on the character of nucleophile.
Databáze:	OpenAIRE
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