Quercetin’s Potential to Prevent and Inhibit Oxidative Stress-Induced Liver Cancer
| Autor: | Ming-Ta Sung, Chin-Wen Chi, Yin-Chiu Chen |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
chemistry.chemical_classification
Reactive oxygen species Antioxidant medicine.medical_treatment Inflammation Biology medicine.disease_cause medicine.disease digestive system diseases chemistry.chemical_compound chemistry Hepatocellular carcinoma Immunology medicine Cancer research heterocyclic compounds Doxorubicin medicine.symptom Liver cancer Quercetin Oxidative stress medicine.drug |
| DOI: | 10.1016/b978-0-12-405205-5.00022-2 |
| Popis: | Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death in the world. Reactive oxygen species (ROS)-induced oxidative stress has been considered a key player in the development and progression of various liver diseases, including viral hepatitis, fibrosis, cirrhosis, and liver cancer (e.g., HCC). In addition to endogenous antioxidants, quercetin available in food is the natural antioxidant to protect humans against oxidative stress. This protective effect is mediated through reducing ROS production, increasing the capacity of DNA repair, and promoting antioxidative responses in cells. In addition, several studies have found that quercetin also has an antiproliferation effect on HCC cells. Moreover, combination treatment with quercetin and chemotherapeutic drug doxorubicin induced a synergistic cytotoxic effect in HCC cells. These results together suggest that quercetin not only has an antioxidative effect to prevent oxidative stress but also has a potential anticancer effect for HCC treatment. |
| Databáze: | OpenAIRE |
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