Cdc48 AAA ATPase Regulates Protein Dynamics and Turnover in Mitochondria
| Autor: | Masatoshi Esaki |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Mitochondrial membrane fusion Biology Protein degradation Mitochondrion AAA proteins Cell biology 03 medical and health sciences Mitochondrial membrane transport protein 030104 developmental biology 0302 clinical medicine mitochondrial fusion Translocase of the inner membrane DNAJA3 biology.protein 030217 neurology & neurosurgery |
| Popis: | Protein degradation contributes to not only the removal of abnormal proteins but also the regulation of biological reactions. The AAA ATPase Cdc48 and the proteasome are widely involved in protein degradation in the cytosol. Cdc48 and the proteasome also regulate quality control of mitochondrial outer membrane proteins including antiapoptotic factors and mitofusins that are responsible for tethering of the mitochondrial outer membrane during fusion events. ATPase-deficient mutants of Cdc48 inhibit mitochondrial fusion and collectively, it has been proposed that mitofusin degradation is required for the progression of mitochondrial membrane fusion. In contrast, recent evidence suggests that Cdc48 may mediate mitochondrial fusion by disassembly of mitofusin tethering complexes. The cytosolic AAA protein thus controls mitochondrial integrity by regulating not only protein stability but also complex formation. This review provides a detailed exploration of how Cdc48 functions to regulate mitochondrial protein quality and morphology. |
| Databáze: | OpenAIRE |
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