The role of coronary sinus in the risk stratification and the prognostic evaluation of idiopathic pulmonary arterial hypertension

Autor: B Uygur, AR Demir, K Sancar, M Yildiz, M Erturk
Rok vydání: 2022
Předmět:
Zdroj: European Heart Journal - Cardiovascular Imaging. 23
ISSN: 2047-2412
2047-2404
DOI: 10.1093/ehjci/jeab289.301
Popis: Funding Acknowledgements Type of funding sources: None. Background Coronary sinus (CS) is a venous structure draining into the right atrium, therefore it can reflect the pressure and the volume load of the right heart chambers. Idiopathic pulmonary arterial hypertension (IPAH) is a progressive, life-threatening disease in which the risk assessment plays a critical role. Purpose We aimed to evaluate the correlation of CS diameter with the well-known risk assessment parameters in IPAH patients and to search the utility of CS diameter in the prediction of mortality and hospitalization. Methods A total of 25 IPAH patients were enrolled in our retrospective study. All patients underwent detailed echocardiographic examination, laboratory examination, 6 minutes walking test and cardiopulmonary exercise test at the same day. The patients were followed-up for a mean 16.8 ± 10.1 months. Primary endpoint was mortality or hospitalization. The relationship between CS diameter and well-known risk parameters and the prognosis were analyzed. Results Mean CS diameter was 9.9 ± 3.7 mm. CS diameter had moderate positive correlation with age (r:0.560, p:0.004), NT-proBNP (r:0.625, p:0.001) and weak positive correlation with functional class (r:0.483, p:0.017) and moderate negative correlation with 6 minutes walking distance (r:-0.553, p:0.005) and peak oxygen uptake (r:-0.506 p:0.038). Six (24%) patients were hospitalized, and three patients (12%) died during mean 16.8 ± 10.1 months follow-up. The CS diameter > 9 mm predicted mortality and hospitalization with a sensitivity of 77.8%, specificity of 75.0% (Area under curve (AUC): 0.788; 95% CI: 0.580-0.996; P = 0.019). Conclusion CS which is a noninvasive, cheap and readily available echocardiographic parameter, might be used in the risk assessment and the evaluation of prognosis in IPAH patients. Abstract Figure. Coronary sinus measurement Abstract Figure. Basal features
Databáze: OpenAIRE
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