| Autor: |
Edward C. Tocus, Donald B. Charleston, George T. Okita, George V. LeRoy |
| Rok vydání: |
1960 |
| Předmět: |
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| Zdroj: |
The International Journal of Applied Radiation and Isotopes. 7:273-286 |
| ISSN: |
0020-708X |
| DOI: |
10.1016/0020-708x(60)90116-2 |
| Popis: |
The majority of carbon compounds of metabolic interest ultimately are degraded to carbon dioxide and urea which are excreted. Following the administration of a tracer dose of a C/sup 14/-labeled metabolite, there is assumed to be a pattern of elimination of C/sup 14/O/sub 2/ which is characteristic for the healthy state, and which is distorted in disease. This pattern is represented by the time-course of specific activity of C/sup 14/O/sub 2/ in expired air. Metabolic studies in human subjects and in animals are facilitated by the apparatus described in this report which permits the continuous measurement of radioactive C/sup 14/O/sub 2/ in expired air. The apparatus consists of an air-collection system, a ventilation meter, a C/sup 12/O/ sub 2/ (infrared) analyzer, a 4 pi G-M counter with anti-coincidence circuitry, and a ratio analyzer to compute C/sup 14//C/sup 12/. Analog data are printed out on a four-channel recording millivoltmeter at the rate of four items per minute on each channel. The data are in such a form that they can be converted readily to digital information for processing in a high-speed computer. Rapid estimates of the size and kinetics of the carbon dioxide pool are possible when labeled bicarbonate is usedmore » as the tracer. (auth)« less |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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