α-Tocopherol protective effects on gentamicin ototoxicity: an experimental study

Autor:	Diana Troiani, Aldo Ferraresi, Anna Rita Fetoni, B Sergi, Gaetano Paludetti
Rok vydání:	2004
Předmět:	Iron Chelator Linguistics and Language medicine.medical_specialty Chemistry Membrane lipid peroxidation Audiology Pharmacology medicine.disease Body weight Language and Linguistics Speech and Hearing Ototoxicity In vivo Anesthesia medicine Gentamicin Tocopherol Corn oil medicine.drug
Zdroj:	International Journal of Audiology. 43:166-171
ISSN:	1708-8186 1499-2027
DOI:	10.1080/14992020400050023
Popis:	Gentamicin, acting as an iron chelator, activates membrane lipid peroxidation (MPL) and induces free radical formation, as observed in vitro and in vivo. Antioxidants, such as α-tocopherol, are able to suppress MLP, thus attenuating tissue damage. The present study was designed to investigate the possible protective effects of α-tocopherol on gentamicin ototoxicity. The study was carried out on albino guinea pigs (250–350 g). The animals were divided into four groups: group A (n = 4), injected with corn oil daily at a dose of 100 mg/kg body weight intramuscularly (IM); group B (n = 10), treated with corn oil at a dose of 100 mg/kg body weight and gentamicin base at a dose of 100 mg/kg body weight (IM); group C (n = 10), treated with gentamicin alone at a dose of 100 mg/kg body weight (IM); and group D (n 10), treated with gentamicin at the same dose plus α-tocopherol acetate at dose of 100 mg/kg body weight (IM). Electrocochleographic recordings were made from an implanted round-window electrode. All anim...
Databáze:	OpenAIRE
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