| Popis: |
The liver is well-known for its ability to regenerate in response to damage. While little is known about the precise molecular mechanism governing liver regeneration, much research has explored the signals and stem cells that hold the potential for liver regeneration. Research has uncovered stem cells isolated in various organs capable of becoming hepatic or hepatic-like cells. Furthermore, in some systems, the signals involved in their transformation have been described. This chapter will review the current knowledge and involvement of stem cells, both hepatic and extrahepatic, in the process of liver regeneration. The therapeutic potential of modulating the natural liver to regenerate during disease, and transplantation of extrahepatic cells will be discussed. |
