A orcadian response to 5‐HTP inhibition of locomotion in the earthworm,lumbricus terrestris
| Autor: | John D. Six, John T. Burns, Robert E. Desmond, Jennifer G. Meloy, James R. Bennett, Amy L. Mielke |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
biology Serotonin synthesis medicine.medical_treatment Earthworm biology.organism_classification Endocrinology Oligochaeta Internal medicine medicine General Earth and Planetary Sciences Serotonin Circadian rhythm Analysis of variance General Agricultural and Biological Sciences Saline Lumbricus terrestris General Environmental Science |
| Zdroj: | Journal of Interdisiplinary Cycle Research. 22:255-260 |
| ISSN: | 0022-1945 |
| DOI: | 10.1080/09291019109360109 |
| Popis: | The effect of DL‐p‐chlorophenylalanine (PCPA) and 5‐hydroxy‐L‐tryptophan (5‐HTP), which influence serotonin levels, were studied with respect to locomotion rates in earthworms, Lumbricus terrestris. The drugs were dissolved in .65% saline and injected into the coelom, and then the rate of locomotion was determined 6 hours later. PCPA, which inhibits serotonin synthesis, increased the rate of locomotion across a distance of 10 cm (19.07 ± 1.07 seconds) as compared to the rate of saline‐injected controls (28.56 ± .96 seconds). In general, saline‐injected earthworms crawled faster than 5‐HTP‐injected earthworms (Student's t test P value less than .0005). Earthworms injected with saline at one of four times of the day crawled fastest at 2400 following injections at 1800 and the responses showed a circadian rhythm (ANOVA P value less than .005 and Cosinor P value less than .001). Earthworms injected 6 hours previously with 5‐HTP crawled slowest at 2400 as compared to the 2400 controls. Among the four ... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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