A bifunctionalized NiCo2O4-Au composite: Intrinsic peroxidase and oxidase catalytic activities for killing bacteria and disinfecting wound
| Autor: | Aiying Guo, Aijun Cai, Yanfeng Sun, Qianzhu Mu, Baoping Qin, Xiaoyue Xu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
021110 strategic defence & security studies Oxidase test Reactive oxygen species Environmental Engineering biology Health Toxicology and Mutagenesis Radical Composite number 0211 other engineering and technologies Biofilm 02 engineering and technology 010501 environmental sciences 01 natural sciences Pollution Combinatorial chemistry Catalysis chemistry biology.protein Environmental Chemistry Waste Management and Disposal 0105 earth and related environmental sciences Antibacterial agent Peroxidase |
| Zdroj: | Journal of Hazardous Materials. 402:123939 |
| ISSN: | 0304-3894 |
| DOI: | 10.1016/j.jhazmat.2020.123939 |
| Popis: | A NiCo2O4-Au composite was fabricated following the calcination-reduction method and testified to exhibit the intrinsic high peroxidase- and oxidase-like activities. The composite could activate a low level of H2O2 (100 μM) to kill E. coli and S. aureus. NiCo2O4-Au composite could be easily separated by an external magnet from the media and reused several times. NiCo2O4-Au composite could also effectively damage the existing biofilms and prevent the formation of new biofilms. The electron spin resonance tests showed that NiCo2O4-Au composite catalyzed H2O2 into reactive oxygen species (ROS), mainly including OH, O2-, and 1O2; while the oxidase-like activity of NiCo2O4-Au also stemmed from the ROS formation in the absence of H2O2. The radical trapping experiment confirmed that OH and 1O2 were the main radicals in the antibacterial process for NiCo2O4-Au in the presence of H2O2. A NiCo2O4-Au based Band-Aid was also designed, which exhibited high anti-infective and wound-healing properties. This study has demonstrated that NiCo2O4-Au composite can be a promising antibacterial agent in environmental and clinical applications. |
| Databáze: | OpenAIRE |
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