| Autor: |
Yolandi Anne Marais, Aaron Saini, Nando Ferreira, Kershinee Reddy, Alexander Zühlke, Nelmarie Rossouw, Stefan Dan Zaharie, Pawel Tomasz Schubert |
| Rok vydání: |
2021 |
| DOI: |
10.21203/rs.3.rs-96041/v2 |
| Popis: |
Adamantinoma-like Ewing sarcoma is a rare variant of Ewing sarcoma known to have histologic and immunohistochemical evidence of squamous differentiation. This variant most commonly occurs in the head and neck region with a few cases reported in long bones of the limbs. It may be associated with poorer clinical outcome and could pose a diagnostic challenge(s) particularly if it occurs in older patients or as a metastatic lesion. We present a case of Ewing sarcoma in the metatarsal of an 11 year old boy that manifested adamantinoma-like morphology after neo-adjuvant chemotherapy. Chemotherapy has been reported to induce neuronal maturation and rhabdoid morphology in cases of Ewing sarcoma, but no reports of treatment induced squamous differentiation with P40/P63 expression have been demonstrated. This is also the first documented case to use a pedicled osteocutaneous fibular transfer in a metatarsal malignancy, which is usually treated by either ray or below knee amputation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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