Molecular Characterization of Inflammation and Staphylococcus aureus Colonization of Involved Skin of Atopic Dermatitis Patients
| Autor: | O. Lejeune, A.M. Schmitt, D. Redoulès, S. Alvarez-Georges, H. Ginisty, C. Rouvrais, C. Casas, C. Viodé |
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| Rok vydání: | 2008 |
| Předmět: |
Pharmacology
medicine.diagnostic_test Physiology business.industry medicine.medical_treatment Case-control study Inflammation Dermatology General Medicine Atopic dermatitis medicine.disease medicine.disease_cause body regions Cytokine Staphylococcus aureus Genotype Immunology Genetic predisposition Medicine SCORAD medicine.symptom business |
| Zdroj: | Skin Pharmacology and Physiology. 21:260-268 |
| ISSN: | 1660-5535 1660-5527 |
| DOI: | 10.1159/000143391 |
| Popis: | Atopic dermatitis (AD) is a multifactorial chronic inflammatory disease mainly stemming from a genetic predisposition that leads to hypersensitivity to environmental factors and a common involvement of Staphylococcus aureus (SA) colonization. The aim of this work was to propose a new non-invasive approach to enumerate the genes coding for the toxins of SA in atopic skin samples. In parallel, the study aimed to evaluate the change in AD through 3 markers of the inflammatory response: IL-8, IL-1RA/IL-1α and IL-18. These methods were tested on 31 patients with AD, and finally on a group of 19 subjects for whom clinical improvement had been reported after various treatments. The study revealed the presence of a large number of genes encoding toxins in atopic samples, indicating a high rate of SA colonization, and also an increase in the level of all cytokine markers in atopic skin compared to the skin of healthy subjects. Finally, we found a positive correlation between increases in the SCORAD (Scoring Atopic Dermatitis Index) value after treatment and the corresponding evolution of the SA density. These methods provide a means to clinically evaluate the course of AD, and may help in the development of potential treatments. |
| Databáze: | OpenAIRE |
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