A practical synthesis of the PPARα agonist, (R)-K-13675, starting from (S)-2-hydroxybutyrolactone

Autor:	Minoru Koura, Takaaki Araki, Kimiyuki Shibuya, Yukiyoshi Yamazaki
Rok vydání:	2008
Předmět:	chemistry.chemical_compound chemistry Pparα agonist Stereochemistry Yield (chemistry) Organic Chemistry Drug Discovery Phenol Ether Enantiomeric excess Biochemistry Trifluoromethanesulfonate Combinatorial chemistry
Zdroj:	Tetrahedron. 64:8155-8158
ISSN:	0040-4020
Popis:	A practical synthesis of optically pure PPARα agonist, (R)-K-13675, is described. This process is based on the use of (S)-2-hydroxybutyrolactone, which can be transformed into the requisite n-butyl (S)-2-hydroxybutanoate in an efficient manner. A key reaction is the etherification between the phenol and n-butyl (S)-2-trifluoromethanesulfonyloxybutanoate to give the phenyl ether in excellent yield without loss of optical purity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::16d2e45dc21dc1736146f4de0de0a14b https://doi.org/10.1016/j.tet.2008.06.049 Zobrazit plný text záznamu Full Text from ScienceDirect