Lignans from the seeds of Arctium lappa L. (burdock) and their inhibitory effects on nitric oxide production

Autor:	Lin-Fen Ding, Na Luo, Li-Jia Huang, Xue Wang, Ya-Dong Guo, Meng-Jie Liang, Jie Bin, Liang Deng, Zhi-Bin Qin
Rok vydání:	2019
Předmět:	Traditional medicine 010405 organic chemistry Chemistry Plant Science 01 natural sciences Biochemistry 0104 chemical sciences Nitric oxide 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Arctium lappa Ic50 values Agronomy and Crop Science Biotechnology
Zdroj:	Phytochemistry Letters. 34:43-49
ISSN:	1874-3900
Popis:	Arctium lappa, commonly known as burdock, is being promoted as a healthy and nutritive food in Chinese societies. This study investigated the roots, seeds, and leaves of burdock in view of its popular uses in traditional Chinese medicine. Seven compounds, including three new ones, were isolated from the seeds of Arctium lappa. Structures of these compounds were examined by conducting extensive spectroscopic analysis. Biological analysis showed that compounds 4, 5, 6, and 7 could inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, and the IC50 values were in the range of 14.7–18.3 μM.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::16d12d49ed1c768174d282ab13fd0d32 https://doi.org/10.1016/j.phytol.2019.09.006 Zobrazit plný text záznamu Full Text from ScienceDirect