Understanding the Pathogenesis of Neurotrophic Keratitis: The Role of Corneal Nerves
| Autor: | Marta Sacchetti, L. Mastropasqua, Mario Nubile, Giacomina Massaro-Giordano |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Trigeminal nerve
Pathology medicine.medical_specialty genetic structures Physiology Regeneration (biology) Neurotrophic keratitis Clinical Biochemistry Cell Biology Anatomy Biology medicine.disease eye diseases Pathogenesis 03 medical and health sciences 0302 clinical medicine Degenerative disease medicine.anatomical_structure Cornea 030221 ophthalmology & optometry medicine sense organs 030217 neurology & neurosurgery Sensory nerve Corneal epithelium |
| Zdroj: | Journal of Cellular Physiology. 232:717-724 |
| ISSN: | 0021-9541 |
| DOI: | 10.1002/jcp.25623 |
| Popis: | Neurotrophic keratitis (NK) is a rare degenerative disease of the cornea caused by trigeminal nerve damage, which leads to loss of corneal sensitivity, corneal epithelium breakdown, and poor healing. Though extremely uncommon, NK is increasingly recognized for its characteristics as a distinct and well-defined clinical entity rather than a rare complication of various diseases that can disrupt trigeminal innervation. Indeed, the defining feature of NK is loss of corneal sensitivity, and its clinical findings do not correlate with the wide range of systemic or ocular conditions that underlie trigeminal nerve damage. Despite increasing awareness of NK as a distinct condition, its management continues to be challenged by the lack of treatments that target nerve regeneration. This review focuses on the role of corneal nerves in maintaining ocular surface homeostasis, the consequences (such as alterations in neuromediators and corneal cell morphology/function) of impaired innervation, and advances in NK diagnosis and management. Novel therapeutic strategies should aim to improve corneal innervation in order support corneal renewal and healing. J. Cell. Physiol. 232: 717-724, 2017. © 2016 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text